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Stefan Hänel

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Stefan Hell. Article Media. Info Print Cite. Submit Feedback. Thank you for your feedback. Home Science Chemistry. Erik Gregersen Erik Gregersen is a senior editor, specializing in the physical sciences and technology.

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Nobel Prize , any of the prizes five in number until , when a sixth was added that are awarded annually from a fund bequeathed for that purpose by the Swedish inventor and industrialist Alfred Nobel.

The Nobel Prizes are widely regarded as the most prestigious awards given for intellectual achievement…. Chemistry , the science that deals with the properties, composition, and structure of substances defined as elements and compounds , the transformations they undergo, and the energy that is released or absorbed during these processes.

Every substance, whether naturally occurring or artificially produced, consists of one or more of the hundred-odd species…. History at your fingertips.

Sign up here to see what happened On This Day , every day in your inbox! However this limitation can be circumvented by methods that make use of fluorescence, a phenomenon in which certain substances become luminous after having been exposed to light.

In , Stefan W. Hell developed a method in which one light pulse causes fluorescent molecules to glow, while another causes all molecules except those in a very narrow area to become dark.

An image is created by sweeping light along the sample. This makes it possible to track processes occurring inside living cells.

Stefan W. Photo: A. Life Stefan Hell was born in Arad, Romania. Work In normal microscopes the wavelength of light sets a limit to the level of detail possible.

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German physicist Ernst Abbe found in that the smallest distance that could be resolved under an optical microscope was about half the wavelength of the light observed.

Thus, for visible light at the shortest possible wavelength of nanometres nm , features smaller than nm would be blurred out, and many features of cells and microorganisms would be impossible to observe.

Other methods, such as electron microscopy , achieve much higher resolutions, but at the cost of preparation methods that kill cells and microorganisms.

During his time at Turku, Hell devised a method for overcoming the Abbe limit through a modified form of fluorescence microscopy , in which molecules that fluoresce when excited by light are attached to very small structures and the resulting emission is observed.

The laser beams are moved over the specimen, and an image is gradually built up. Since then, resolutions of less than 10 nm have been achieved, thus enabling the microscopic study of active viruses and of molecules in living cells.

Stefan Hell. Article Media. Info Print Cite. Submit Feedback. Thank you for your feedback. Home Science Chemistry.

Erik Gregersen Erik Gregersen is a senior editor, specializing in the physical sciences and technology. See Article History.

Get exclusive access to content from our First Edition with your subscription. Subscribe today. Learn More in these related Britannica articles:.

Moerner and Romanian-born German chemist Stefan Hell. This makes it possible to track processes occurring inside living cells.

Stefan W. Photo: A. Life Stefan Hell was born in Arad, Romania. Work In normal microscopes the wavelength of light sets a limit to the level of detail possible.

Back to top Back To Top Takes users back to the top of the page. Nobel Prizes Fifteen laureates were awarded in , for achievements that have conferred the greatest benefit to humankind.

Their work and discoveries range from how cells adapt to changes in levels of oxygen to our ability to fight global poverty.

See them all presented here.